Causal variants & genes
Identifying genetic variants and genes involved in retinal and macular degenerative diseases.
Baylor College of Medicine · Houston, Texas
Connecting genomics, computational biology, and molecular research to uncover the mechanisms of retinal and macular degeneration.
Our research
Understanding the role of genetic variations leading to retinal and macular degenerative diseases represents the central theme of our research. Large-scale genomic studies have demonstrated the massive scale of genetic variations among individuals, which have revealed important insights into genetic diversity and disease susceptibility.
We focus on harnessing the power of genomic technologies to address translational and clinical bioinformatic challenges pertaining to retinal and macular degenerative diseases. We generate multiple high-throughput functional genomics data sets on the genome, transcriptome and epigenome in disease-relevant tissues/cells and use computational approaches to integrate and analyze this data to identify the molecular components and the structure of the regulatory apparatus underlying the disease.
Identifying genetic variants and genes involved in retinal and macular degenerative diseases.
Annotating variants and genes at tissue and single-cell resolution.
Identifying the molecular and cellular pathways associated with disease.
Developing appropriate models to investigate disease mechanisms.
People & discoveries
I am an Assistant Professor in the Department of Ophthalmology at Baylor College of Medicine, where my research focuses on the genetics of retinal and macular degenerative diseases. I integrate genomic, transcriptomic, and epigenetic data to identify causal genes and mechanisms underlying neurodegeneration and vision loss. I earned my Ph.D. in Human Genetics from JNCASR, India, and completed postdoctoral training in ocular genomics at the National Eye Institute. Outside of work, I enjoy spending quality time with my family and exploring the outdoors. Meet PI
I did my PhD in Bioinformatics from NIPGR, New Delhi, India in 2022 and joined RatnapriyaLab in March 2023. My reserch intrests include the coding, non-coding RNAs, and multiomic/integrative analysis. Currently I am focusing on genomics study of IRD and AMD diseases.
I am a Ph.D. biologist with expertise in endocrinology, physiology, molecular genetics, evolution, and bioinformatics. My research explores how molecular and endocrine signaling pathways regulate development, tissue function, and physiological responses. I completed my doctoral research at Colorado State University, where I investigated the molecular mechanisms regulating molting in decapod crustaceans. My background bridges experimental and computational biology, with experience in RNA-seq, transcriptomics, gene expression analysis, comparative phylogenetics, molecular biology, and hormone quantification. My broader research experience includes developmental biology, insect physiology, metamorphosis, and mosquito transcriptomics. I am passionate about understanding how changes in gene regulation and molecular signaling translate into physiological outcomes. I bring an interdisciplinary approach to biological research, along with experience in teaching, student mentorship, and research training.
I am a freshman studying bioengineering at Rice University, serving as an undergraduate researcher here at the RatnapriyaLab! I am passionate about understanding the genetic basis behind common conditions as a part of the effort of developing “personalized medicine.” In particular, I am translating this passion to age-related macular degeneration (AMD), where I am analyzing single-cell sequencing data of the retina to construct a picture of the diverse cell types at play in AMD. I am so excited to continue my work at the RatnapriyaLab!
I am first-year medical student at Baylor College of Medicine. I did my graduation from Dartmouth College in 2023, with a major in Quantitative Social Science and a minor in Public Policy. My background as an ophthalmic assistant sparked an early interest in eye health, and I am very excited to contribute to research at the intersection of genetics and ophthalmology.
3. Pinal Koladiya
2. Khang Ma
1. Hosei Nakajima
Undergraduate students
5. Lauren Wu
4. Olivia Kaneko
3. Anya Sathyajit
2. Jayden Kim
1. Sophiya Sami
1. Ma K, Ratnapriya R. Molecular and genetic landscapes of retina and brain microglia in neurodegenerative diseases. Genome Res. 2025 Oct;35(10):2143-2157. doi: 10.1101/gr.280554.125. PMID: 40858363; PMCID: PMC12487699
2. Khang Ma, Hosei Nakajima, Nipa Basak, Arko Barman, Rinki Ratnapriya. Integrating explainable machine learning and transcriptomics data reveals cell-type specific immune signatures underlying macular degeneration. npj Genomic Medicine
3. Ratnapriya R, Grassman F, Chen R, Hewitt A, Du J, Saban DR, Klaver CCW, Ash J, Stambolian D, Tumminia SJ, Qian J, Husain D, Iyengar SK, den Hollander AI. Functional genomics in age-related macular degeneration: From genetic associations to understanding disease mechanisms. Exp Eye Res. 2025 May;254:110344. doi: 10.1016/j.exer.2025.110344. Epub 2025 Mar 13. PMID: 40089136; PMCID: PMC12048874
4. Singh A, Ratnapriya R. Integration of multiomic data identifies core-module of inherited-retinal diseases. Hum Mol Genet. 2025 Feb 17;34(5):454-465. doi: 10.1093/hmg/ddaf001. PMID: 39797395
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