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RatnapriyaLab

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Research

Understanding the role of genetic variations leading to retinal and macular degenerative diseases represent the central theme of our research. Large-scale genomic studies have demonstrated the massive scale of genetic variations among individuals, which have revealed important insights into genetic diversity and disease susceptibility.

We focus on harnessing the power of genomic technologies to address translational and clinical bioinformatic challenges pertaining to retinal and macular degenerative diseases. We generate multiple high-throughput functional genomics data sets on the genome, transcriptome and epigenome in disease-relevant tissues/cells and use computational approaches to integrate and analyze this data to identify the molecular components and the structure of the regulatory apparatus underlying the disease.

Our ongoing projects are related to the following:

(i) Identification of causal variants and genes in retinal and macular degenerative diseases

(ii) Annotating variants and genes at tissues and single-cell resolution

(iii) Identifying molecular and cellular pathways associated with the disease

(iv) Developing appropriate disease models to infer disease mechanisms


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About the RatnapriyaLab

Meet Current Lab Members
Rinki Ratnapriya, PhD
PI

I am an Assistant Professor in the Department of Ophthalmology at Baylor College of Medicine, where my research focuses on the genetics of retinal and macular degenerative diseases. I integrate genomic, transcriptomic, and epigenetic data to identify causal genes and mechanisms underlying neurodegeneration and vision loss. I earned my Ph.D. in Human Genetics from JNCASR, India, and completed postdoctoral training in ocular genomics at the National Eye Institute. Outside of work, I enjoy spending quality time with my family and exploring the outdoors. Meet PI


Ajeet Singh, PhD
Postdoc Associate

I did my PhD in Bioinformatics from NIPGR, New Delhi, India in 2022 and joined RatnapriyaLab in March 2023. My reserch intrests include the coding, non-coding RNAs, and multiomic/integrative analysis. Currently I am focusing on genomics study of IRD and AMD diseases.



Vanessa Bentley
Vanessa Bentley
Postdoc Associate

I am a Ph.D. biologist with expertise in endocrinology, physiology, molecular genetics, evolution, and bioinformatics. My research explores how molecular and endocrine signaling pathways regulate development, tissue function, and physiological responses. I completed my doctoral research at Colorado State University, where I investigated the molecular mechanisms regulating molting in decapod crustaceans. My background bridges experimental and computational biology, with experience in RNA-seq, transcriptomics, gene expression analysis, comparative phylogenetics, molecular biology, and hormone quantification. My broader research experience includes developmental biology, insect physiology, metamorphosis, and mosquito transcriptomics. I am passionate about understanding how changes in gene regulation and molecular signaling translate into physiological outcomes. I bring an interdisciplinary approach to biological research, along with experience in teaching, student mentorship, and research training.



Vaishnavi
Vaishnavi Mallagundla
Research Technician

I graduated from Rice University with a Master's degree in Computer Science. I have joined the RatnapriyaLab in September 2026. I am passionate about translating my knowledge in Computer Science into the field of biology and medicine.



Anika Kulkarni
Undergraduate researcher

I am a freshman studying bioengineering at Rice University, serving as an undergraduate researcher here at the RatnapriyaLab! I am passionate about understanding the genetic basis behind common conditions as a part of the effort of developing “personalized medicine.” In particular, I am translating this passion to age-related macular degeneration (AMD), where I am analyzing single-cell sequencing data of the retina to construct a picture of the diverse cell types at play in AMD. I am so excited to continue my work at the RatnapriyaLab!



Vandana Venkatesh
Medical student

I am first-year medical student at Baylor College of Medicine. I did my graduation from Dartmouth College in 2023, with a major in Quantitative Social Science and a minor in Public Policy. My background as an ophthalmic assistant sparked an early interest in eye health, and I am very excited to contribute to research at the intersection of genetics and ophthalmology.



Lahari Chennupati
Lahari Chennupati
Undergraduate Researcher



Neva Aygar
Neva Aygar
Undergraduate Researcher



Daniel Song
Daniel Song
Undergraduate Researcher



Shaafae
Shaafae Chaudhary
Undergraduate Researcher


Past Members

3. Pinal Koladiya

2. Khang Ma

1. Hosei Nakajima

Undergraduate students

5. Lauren Wu

4. Olivia Kaneko

3. Anya Sathyajit

2. Jayden Kim

1. Sophiya Sami

Recent Publications

1. Khang Ma, Hosei Nakajima, Nipa Basak, Arko Barman, Rinki Ratnapriya. Integrating explainable machine learning and transcriptomics data reveals cell-type specific immune signatures underlying macular degeneration. npj Genomic Medicine

2. Ratnapriya R, Grassman F, Chen R, Hewitt A, Du J, Saban DR, Klaver CCW, Ash J, Stambolian D, Tumminia SJ, Qian J, Husain D, Iyengar SK, den Hollander AI. Functional genomics in age-related macular degeneration: From genetic associations to understanding disease mechanisms. Exp Eye Res. 2025 May;254:110344. doi: 10.1016/j.exer.2025.110344. Epub 2025 Mar 13. PMID: 40089136; PMCID: PMC12048874

3. Singh A, Ratnapriya R. Integration of multiomic data identifies core-module of inherited-retinal diseases. Hum Mol Genet. 2025 Feb 17;34(5):454-465. doi: 10.1093/hmg/ddaf001. PMID: 39797395


For more publications, please visit NCBI or Google Scholar.
Funding and Support

Dr. Ratnapriya was awarded 2021 Research to Prevent Blindness Career Development Award. She is also funded by BrightFocus New Investigator Grant, and Foundation Fighting Blindness Individual Investigator Award.

RPB BFF

FFB

Open Positions

The lab has open position for research assistant, postdoc and graduate student. We are looking for talented people interested in genomics, transcriptomics, epigenomics, computational biology, statistics, and/or molecular biology.

If you are interested in joining the lab, please send your CV and a cover letter to Rinki Ratnapriya, PhD.
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Meet PI

Rinki Ratnapriya, Ph.D

Dr. Ratnapriya is an Assistant Professor in the Department of Ophthalmology, Baylor College of Medicine, Houston TX, USA. Identification of the causal genes/variants and understanding their roles in neurodegenerative diseases represent the central theme of her research. She earned her B.Sc. from Delhi University in India.

News



Publications

May 2025

Khang's paper was accepted in npj | Genomic Medicine

Congratulations, Khang!
Link for paper

December 2024

Ajeet's paper was accepted for publication in Human Molecular Genetics.

Congratulations, Ajeet!
HMG


For more NEWS click here.

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